Guidelines and Recommendation
The National Comprehensive Cancer Network (NCCN) is an alliance of 28 leading cancer centers with experts who meet annually to make recommendations on hereditary cancer care. NCCN updates their guidelines for genetic counseling and testing guidelines based on the most up to date research. The following guidelines are used as standard of care. NCCN's referral recommendation to a genetic counselor for evaluation of cancer patients and people with a family history of cancer if they meet any one of the following criteria:
| Anyone with blood relative with a known mutation in a gene that increases cancer risk. |
| Anyone with cancer who had a tumor test result that showed a mutation in a gene that increases cancer risk. |
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Anyone diagnosed with:
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Ovarian, fallopian tube, or primary peritoneal cancer
- Pancreatic cancer
- Metastatic prostate cancer
- Breast or high-grade prostate cancer and an Ashkenazi Jewish ancestor
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Anyone with breast cancer and any of the following:
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Diagnosed at or before age 50
- Triple negative breast cancer
- Two separate breast cancer diagnoses
- A close relative with ovarian, male breast, high- grade prostate or pancreatic cancer
- Two close relative diagnosed with breat cancer at any age
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Anyone who has a close relative with any of the following:
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Breast cancer at or before age 45
- Ovarian, fallopian tube, or primary peritoneal cancer
- Male breast cancer
- Pancreatic cancer
- Metastatic prostate cancer
- Two separate breast cancer diagnoses
- Or two or more close relatives with breast cancer with at least one diagnosed before age 50
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Anyone with a personal or family history of three or more of the following, especially if any of the cases are diagnosed before age 50:
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- Prostate cancer
- Melanoma
- Sarcoma
- Adrenal cancer
- Brain tumors
- Leukemia
- Uterine cancer
- thyroid cancer
- Kidney cancer
- Diffuse gastric cancer
- Colon cancer
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